Question 1 · Surgery, Clinical
A 52-year-old woman has had dull right upper quadrant discomfort and bloating for 4 months. She is afebrile with a pulse of 76 per minute. A smooth, soft, non-tender, pear-shaped mass moves with respiration below the right costal margin. White cell count, CRP, bilirubin, and alkaline phosphatase are normal. Ultrasound shows a markedly distended thin-walled gallbladder with clear contents, a stone impacted in the neck, and a 5 mm bile duct. Which management is most appropriate?
- A. Reassurance with no follow-up
- B. Ursodeoxycholic acid to dissolve the stone
- C. Endoscopic clearance of the bile duct
- D. Elective laparoscopic cholecystectomy
- E. Percutaneous cholecystostomy with antibiotics
Show the answer and explanation
Answer: D. Elective laparoscopic cholecystectomy
A large, soft, non-tender palpable gallbladder in an afebrile patient, with clear contents behind a stone impacted in the neck, is a mucocele (hydrops): obstruction without infection, with the gallbladder distended by mucus. It causes dull pain and dyspepsia and can become infected or perforate, so the definitive treatment is cholecystectomy, done laparoscopically and electively because she is well. Normal markers rule against empyema, and the normal duct and liver tests rule out duct stones.
Why the other options are wrong
- A. Reassurance with no follow-up: An obstructed, distended gallbladder causing symptoms is not a silent stone; it can become infected or perforate.
- B. Ursodeoxycholic acid to dissolve the stone: Bile acid therapy needs a functioning gallbladder with small cholesterol stones; it cannot clear a stone impacted in the neck.
- C. Endoscopic clearance of the bile duct: Duct clearance treats common bile duct stones; her duct is 5 mm with normal liver tests, and the problem is in the gallbladder neck.
- E. Percutaneous cholecystostomy with antibiotics: Drainage treats an infected gallbladder in a patient too unwell for surgery; she is afebrile with normal inflammatory markers.
Key point: A soft, non-tender, distended gallbladder with clear contents behind an impacted neck stone in a well patient is a mucocele; treat it with elective laparoscopic cholecystectomy.
References
- Incidental gallbladder mucocele mimicking acute cholecystitis: a case report and review of literature, World Journal of Experimental Medicine 2025 (Europe PMC full text)
- Gallbladder hydrops, Radiopaedia