Question 1 · Dermatology, Clinical
During methotrexate monitoring, white-cell counts steadily fall and liver enzymes rise across several visits, while the latest values remain inside the laboratory reference limits. Which interpretation is best?
- A. Continue routine monitoring at the planned interval
- B. Review the skin response for possible dose escalation
- C. Review possible toxicity from the serial trends
- D. Seek urgent assessment of a dosing overdose
- E. Review whether the folate schedule is documented
Show the answer and explanation
Answer: C. Review possible toxicity from the serial trends
Gradual falling counts or rising enzymes may warn of toxicity even before an absolute threshold is exceeded.
Why the other options are wrong
- A. Continue routine monitoring at the planned interval: Continue routine monitoring at the planned interval would fit serial counts and organ results are stable and reassuring with no new clinical concern. In this case, progressively falling counts and rising liver enzymes can matter before an absolute limit is crossed.
- B. Review the skin response for possible dose escalation: Review the skin response for possible dose escalation would fit efficacy is inadequate and the safety assessment supports an indicated specialist change. In this case, progressively falling counts and rising liver enzymes can matter before an absolute limit is crossed.
- D. Seek urgent assessment of a dosing overdose: Seek urgent assessment of a dosing overdose would fit excess dosing or acute toxicity symptoms indicate an immediate overdose concern. In this case, progressively falling counts and rising liver enzymes can matter before an absolute limit is crossed.
- E. Review whether the folate schedule is documented: Review whether the folate schedule is documented would fit the issue is missing supplementation instructions rather than changing blood-count and liver trends. In this case, progressively falling counts and rising liver enzymes can matter before an absolute limit is crossed.
Key point: Use serial blood-count and liver trends in methotrexate safety review.
References
- Methotrexate monitoring, NHS SPS